General Information

  • ID:  hor005357
  • Uniprot ID:  P01144
  • Protein name:  Sauvagin
  • Gene name:  NA
  • Organism:  Phyllomedusa sauvagei (Sauvage's leaf frog)
  • Family:  Sauvagine/corticotropin-releasing factor/urotensin I family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Phyllomedusa (genus), Phyllomedusinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI
  • Length:  40(1-40)
  • Propeptide:  QGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T40 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hypotensive and diuretic peptide.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01144-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01144-F1.pdbhor005357_AF2.pdbhor005357_ESM.pdb

Physical Information

Mass: 531323 Formula: C202H348N56O64S
Absent amino acids: CFHVWY Common amino acids: L
pI: 4.85 Basic residues: 6
Polar residues: 6 Hydrophobic residues: 14
Hydrophobicity: -53.5 Boman Index: -8239
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 122
Instability Index: 7202.75 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7309372
  • Title:  Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei.
  • PubMed ID:  7118402
  • Title:   Primary structure of sauvagine.
  • PubMed ID:  6981615
  • Title:   Secondary structure prediction of sauvagine, a novel biologically active polypeptide from a frog.